Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
نویسندگان
چکیده
منابع مشابه
Cdk5-Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models.
Deregulated Cdk5 causes neurotoxic amyloid beta peptide (Aβ) processing and cell death, two hallmarks of Alzheimer's disease, through the Foxo3 transcriptional factor in hippocampal cells, primary neurons and an Alzheimer's disease mouse model. Using an innovative chemical genetic screen, we identified Foxo3 as a direct substrate of Cdk5 in brain lysates. Cdk5 directly phosphorylates Foxo3, whi...
متن کاملCdk5: a multifaceted kinase in neurodegenerative diseases.
Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an array of neurodegenerative diseases. As knowledge on the etiopathological mechanisms of these diseases evolved through the years, Cdk5 has also been implicated in additional cellular events that are affected under thes...
متن کاملNeuroprotective mechanisms of statins in neurodegenerative diseases
Statins can induce neuroprotective effects by various mechanisms, such as by lowering cholesterol levels; decreasing β-amyloid production, serum apolipoprotein E (APOE) levels, and anti-inflammatory responses; modifying cognition-related receptors, and augmenting endothelial nitric oxide synthase. The use of statins has been related to many neurodegenerative conditions, such as Alzheimer’s dise...
متن کاملGlucose Role in Treatment of Alzheimers’ Disease
1. Dong H, Csernansky JG (2009) Effects of Stress and Stress Hormones on Amyloidβ Protein and Plaque Deposition. J Alzheimers Dis 18: 459-469. 2. Csernansky JG, Dong H, Fagan AM, Wang L, Xiong C, et al. (2006) Plasma cortisol and progression of dementia in subjects with Alzheimer‐ type dementia. Am J Psychiatry 163: 2164-2169. 3. Swaab DF, Raadsheer FC, Endert E, Hofman MA, Kamphorst W, et al. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2016
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.185009